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Nanotech Medicine to Rebuild Damaged Parts of Human Body



To rebuild damaged parts of a human body from scratch is a dream that has long fired human imagination, from Mary Shelley's Doctor Frankenstein to modern day surgeons. Now, a team of European scientists, working in the frame of the EUREKA project ModPolEUV, has made a promising contribution to reconstructive surgery, thanks to an original multidisciplinary approach matching cutting-edge medicine to the latest developments in nanotechnology.According to the World Health Organisation (WHO), an estimated 322,000 deaths globally per year are linked to severe injuries from fire and in many of these cases death could have been avoided with surgical intervention.

In this type of intervention, when major burn patients have insufficient skin left to graft on the most damaged part of their body, new skin has literally to be grown from the patient's own skin cells. However, the long delay in growing the skin can expose the burns patient to increased risk of infection and dehydration; so to help those cells to multiply, specialists use a particular kind of component called polymeric material. Because of their extraordinary range of properties, polymeric materials play a ubiquitous role in our daily life. This role ranges from familiar synthetic plastics: plastic bags or yoghurt cups, to natural biopolymers such as wood or proteins that are present in the human body.

New nano-structured materials

It has been known for the last few years that man made synthetic polymeric materials have the potential to grow and multiply human cells. 'About 10 years ago, scientists discovered the important influence that nano-structures had on the way a line of cells would develop. It was the beginning of an entire new scientific field, somewhere between medicine and nanotechnology,' says Professor Johannes Heitz, Senior Research Associate at the University of Linz, Austria and main coordinator of the ModPolEUV project.

In the case of human skin cells, re-implantation of the tissue can be performed once a sufficient amount of skin is obtained, by growing it on a polymeric material surface.

However, in many cases, imperfections in the material structure can make the process relatively long and sometimes inefficient, with cells developing erratically.

The team of Austrian, Czech and Polish scientists involved in the research project managed to develop a new and simple way to create nano-structured materials that would allow a better development of human cells.

The Polish partner in the team, the Military University of Technology of Warsaw, has been in charge of the development of the new laser-based technology called EUV (Extreme Ultra-Violet) that was used for the creation of the nano-structured polymer surfaces. A beam of EUV light formed with a unique mirror developed by the Czech partner REFLEX S.R.O is directed on the surface allowing the creation of new kinds of polymeric materials. This innovative technique allows for a very high degree of precision, from 10 to 20 nanometres, whereas conventional techniques allowed only for a maximal precision level of 100 nanometres. 'One of the newest theories in the field of cell growing is that the smaller the structure, the wider the possibilities to manipulate cells,' says Professor Heitz.

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